Letter to the editor: “Urothelial barrier dysfunction: cause or outcome of ketamine-induced voiding dysfunction”

Letter to the editor: "Urothelial barrier dysfunction: cause or outcome of ketamine-induced voiding dysfunction".

TO THE EDITOR: Ketamine-induced cystitis was first reported by Shahani et al. in 2007 (6). Clinical presentations of this entity is characterized by lower urinary tract symptoms (LUTS), such as frequency, urgency, gross hematuria, and bladder pain (2, 6). The underlying mechanisms are still unelucidated in ketamine-induced cystitis, and the approaches to therapy include cessation of ketamine, m...

Reply to "Letter to the editor: 'Urothelial barrier dysfunction: cause or outcome of ketamine-induced voiding dysfunction'".

REPLY: We would like to thank Wang et al. (3) for their interest in and comment on our article. Since the first report of ketamine cystitis by Shahani et al. (2) 10 years ago, the mechanism of this new urinary dysfunction is still a mystery. Ketamine is accumulated in urine, and urothelial ulceration is commonly observed in severe ketamine cystitis patients, which might be the major reason for ...

Intact urothelial barrier function in a mouse model of ketamine-induced voiding dysfunction.

Ketamine is a popular choice for young drug abusers. Ketamine abuse causes lower urinary tract symptoms, with the underlying pathophysiology poorly understood. Disruption of urothelial barrier function has been hypothesized to be a major mechanism for ketamine cystitis, yet the direct evidence of impaired urothelial barrier function is still lacking. To address this question, 8-wk-old female C5...

Letter to the editor: "Targeting cerebrovascular myogenic dysfunction in stroke".

Francesc Jiménez-Altayó, Anna María Planas, and Elisabet Vila Departament de Farmacologia, Terapèutica i Toxicologia, Institut de Neurociències, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra; and Departament d’Isquèmia Cerebral i Neurodegeneració, Institut de Recerca Biomèdica, Consejo Superior de Investigaciones Científicas, Institut d’Investigacions Biomèdiques August Pi...

Letter to the editor